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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
TOP3A
All Species:
11.52
Human Site:
S896
Identified Species:
16.89
UniProt:
Q13472
Number Species:
15
Phosphosite Substitution
Charge Score:
-0.27
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q13472
NP_004609.1
1001
112372
S896
D
G
S
G
S
G
T
S
C
L
C
S
Q
P
S
Chimpanzee
Pan troglodytes
XP_511323
1001
112378
S896
D
G
S
G
S
G
T
S
C
L
C
S
Q
P
S
Rhesus Macaque
Macaca mulatta
XP_001095437
1001
112278
S896
D
G
S
G
T
G
T
S
C
L
C
S
Q
P
A
Dog
Lupus familis
XP_546656
989
110956
C887
G
R
G
M
A
C
L
C
S
Q
P
A
V
T
R
Cat
Felis silvestris
Mouse
Mus musculus
O70157
1003
112340
P898
S
D
S
D
G
G
T
P
C
L
C
G
Q
P
A
Rat
Rattus norvegicus
XP_002742497
1001
111922
S896
G
D
G
D
G
G
A
S
C
L
C
G
Q
P
A
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001510142
1042
116269
V938
G
G
D
S
G
G
A
V
C
M
C
N
Q
P
A
Chicken
Gallus gallus
NP_001025807
1020
114626
V915
S
S
S
G
D
S
T
V
C
R
C
D
Q
P
A
Frog
Xenopus laevis
NP_001085699
1022
114003
V912
G
S
E
G
Q
A
V
V
C
M
C
N
Q
P
A
Zebra Danio
Brachydanio rerio
XP_688695
998
112490
G892
Q
Q
R
Q
N
H
R
G
S
G
G
D
E
G
E
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Q9NG98
1250
136119
C1035
P
E
S
E
T
V
L
C
T
G
C
Q
Q
P
A
Honey Bee
Apis mellifera
XP_394050
958
109977
K855
Y
N
V
A
T
I
V
K
C
N
C
N
Q
L
A
Nematode Worm
Caenorhab. elegans
O61660
759
85420
K659
P
R
G
R
P
P
R
K
S
I
S
P
A
V
K
Sea Urchin
Strong. purpuratus
XP_782119
679
77025
A579
K
N
P
E
D
V
L
A
E
Q
V
D
K
Y
K
Poplar Tree
Populus trichocarpa
XP_002307047
910
102138
R808
C
G
T
P
C
V
L
R
T
A
N
T
A
N
N
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
NP_201197
926
103389
R826
N
T
E
A
N
R
G
R
Q
F
F
S
C
P
T
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
99
94.9
87.7
N.A.
86.8
83.8
N.A.
72.8
73
70.9
66.5
N.A.
41.2
46.8
38.5
47
Protein Similarity:
100
99.6
97
91.1
N.A.
91.5
88.9
N.A.
80.5
82.9
81.8
80.3
N.A.
53.7
63.7
50.8
57
P-Site Identity:
100
100
86.6
0
N.A.
53.3
46.6
N.A.
40
46.6
33.3
0
N.A.
26.6
20
0
0
P-Site Similarity:
100
100
100
13.3
N.A.
60
53.3
N.A.
60
53.3
53.3
13.3
N.A.
40
40
6.6
13.3
Percent
Protein Identity:
40
N.A.
N.A.
38.8
N.A.
N.A.
Protein Similarity:
56.3
N.A.
N.A.
54.5
N.A.
N.A.
P-Site Identity:
6.6
N.A.
N.A.
13.3
N.A.
N.A.
P-Site Similarity:
26.6
N.A.
N.A.
33.3
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
0
13
7
7
13
7
0
7
0
7
13
0
50
% A
% Cys:
7
0
0
0
7
7
0
13
57
0
63
0
7
0
0
% C
% Asp:
19
13
7
13
13
0
0
0
0
0
0
19
0
0
0
% D
% Glu:
0
7
13
13
0
0
0
0
7
0
0
0
7
0
7
% E
% Phe:
0
0
0
0
0
0
0
0
0
7
7
0
0
0
0
% F
% Gly:
25
32
19
32
19
38
7
7
0
13
7
13
0
7
0
% G
% His:
0
0
0
0
0
7
0
0
0
0
0
0
0
0
0
% H
% Ile:
0
0
0
0
0
7
0
0
0
7
0
0
0
0
0
% I
% Lys:
7
0
0
0
0
0
0
13
0
0
0
0
7
0
13
% K
% Leu:
0
0
0
0
0
0
25
0
0
32
0
0
0
7
0
% L
% Met:
0
0
0
7
0
0
0
0
0
13
0
0
0
0
0
% M
% Asn:
7
13
0
0
13
0
0
0
0
7
7
19
0
7
7
% N
% Pro:
13
0
7
7
7
7
0
7
0
0
7
7
0
63
0
% P
% Gln:
7
7
0
7
7
0
0
0
7
13
0
7
63
0
0
% Q
% Arg:
0
13
7
7
0
7
13
13
0
7
0
0
0
0
7
% R
% Ser:
13
13
38
7
13
7
0
25
19
0
7
25
0
0
13
% S
% Thr:
0
7
7
0
19
0
32
0
13
0
0
7
0
7
7
% T
% Val:
0
0
7
0
0
19
13
19
0
0
7
0
7
7
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
7
0
0
0
0
0
0
0
0
0
0
0
0
7
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _